parkinsons

Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson‘s disease.

Abstract

INTRODUCTION:

Mitochondrial complex I deficiencies have been found in post-mortem brains of patients with Parkinson‘s disease (PD). Coenzyme Q10 (CoQ10) is the electron acceptor found in complexes I and II, and is a potent antioxidant. A recent trial of the oxidized form of CoQ10 for PD failed to show benefits; however, the reduced form of CoQ10 (ubiquinol-10) has shown better neuroprotective effects in animal models.

METHODS:

Randomized, double-blind, placebo-controlled, parallel-group pilot trials were conducted to assess the efficacy of ubiquinol-10 in Japanese patients with PD. Participants were divided into two groups: PD experiencing wearing off (Group A), and early PD, without levodopa (with or without a dopamine agonist) (Group B). Participants took 300 mg of ubiquinol-10 or placebo per day for 48 weeks (Group A) or 96 weeks (Group B).

RESULTS:

In Group A, total Unified Parkinson‘s Disease Rating Scale (UPDRS) scores decreased in the ubiquinol-10 group (n = 14; mean ± SD [-4.2 ± 8.2]), indicating improvement in symptoms. There was a statistically significant difference (p < 0.05) compared with the placebo group (n = 12; 2.9 ± 8.9). In Group B, UPDRS increased in the ubiquinol-10 group (n = 14; 3.9 ± 8.0), as well as in the placebo group (n = 8; 5.1 ± 10.3).

CONCLUSIONS:

This is the first report showing that ubiquinol-10 may significantly improve PD with wearing off, as judged by total UPDRS scores, and that ubiquinol-10 is safe and well tolerated.

 

About the author: Dr. Mordy Levy

 

Dr. Mordy Levy, ND, DC, HOM, is possibly the only Canadian doctor to have graduated from three first professional doctorates in separate and distinct health care professions: Chiropractic Medicine (DC)-1997, Allopathic Medicine (MD)-2006, Naturopathic Medicine (ND)-2011, graduated Summa Cum Laude, from the prestigious National University of Health Sciences (Chicago, IL) and was the valedictorian of his graduating class. Dr Levy's first undergraduate degree (BSc) was in Biology and Psychology from York University, and his second undergraduate degree (BMSc) was in Human Biology and Biomedical sciences from National University of Health Sciences (Chicago, IL)

Dr. Levy is a registered member in good standing with three distinct health professions in Ontario, namely the College of Chiropractors of Ontario, the College of Naturopaths of Ontario, in addition to the College of Homeopaths of Ontario. Dr. Levy is a professional member of the Institute of Functional Medicine, the Canadian Society of Orthomolecular Medicine, American College of Nutrition, in addition to the Ontario Association of Naturopathic Doctors, the Ontario Chiropractic Association and the Ontario Homeopathic Association. Always an avid lifelong learner, Dr. Levy completed numerous postgraduate certifications in Functional Medicine, Clinical Nutrition, Medical Acupuncture, Homeopathic Medicine, in addition to Prolotherapy regenerative medicine. His clinical interests are in Neurological, Autoimmune and Gastrointestinal Dysfunctions.
On a personal noted: Dr. Levy enjoys spending time with his two boys, practicing TaeKwonDo and reviewing research articles.

Website: http://www.DrLevy.ca