High dose of Omega 3 and Vitamin D3 affects clinical symptoms of Multiple sclerosis


High-dose Omega-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial.

Abstract

BACKGROUND:

Combined omega-3 fatty acid and vitamin D3 supplementation may improve multiple sclerosis (MS) by correcting metabolic abnormalities and attenuating oxidative stress and inflammation.

OBJECTIVE:

This study aimed to determine the effects of Omega-3 fatty acid and vitamin D3 co-supplementation on the disability score and metabolic status of patients with MS.

METHODS:

This was a randomized, placebo-controlled clinical trial with Expanded Disability Status Scale (EDSS) score and inflammation as primary outcomes and oxidative stress biomarkers and metabolic profile as secondary outcomes. Patients, aged 18-55 y, were matched for disease EDSS scores, gender, medications, BMI, and age (n = 53) and randomly received a combined 2 × 1000 mg/d  Omega-3 fatty acid and 50,000 IU/biweekly cholecalciferol supplement or placebo for 12 wk. The placebos were matched in colour, shape, size, packaging, smell, and taste with supplements. Fasting blood samples were collected at baseline and end of intervention to measure different outcomes. Multiple linear regression models were used to assess treatment effects on outcomes adjusting for confounding variables.

RESULTS:

Patients taking Omega-3 fatty acid plus vitamin D3 supplements showed a significant improvement in EDSS (? -0.18; 95% CI: -0.33, -0.04; P = 0.01), compared with placebo. Serum high-sensitivity C-reactive protein (? -1.70 mg/L; 95% CI: -2.49, -0.90 mg/L; P < 0.001), plasma total antioxidant capacity (? +55.4 mmol/L; 95% CI: 9.2, 101.6 mmol/L; P = 0.02), total glutathione (? +51.14 µmol/L; 95% CI: 14.42, 87.87 µmol/L; P = 0.007), and malondialdehyde concentrations (? -0.86 µmol/L; 95% CI: -1.10, -0.63 µmol/L; P < 0.001) were significantly improved in the supplemented group compared with the placebo group. In addition, ?-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations.

CONCLUSION:

Overall, taking Omega-3 fatty acid and vitamin D3 supplements for 12 wk by patients with MS had beneficial effects on EDSS and metabolic status.

Reference:

Kouchaki E, Afarini M, Abolhassani J, Mirhosseini N, Bahmani F, Masoud SA,
Asemi Z. High-dose ?-3 Fatty Acid Plus Vitamin D3 Supplementation Affects
Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A
Randomized Controlled Clinical Trial. J Nutr. 2018 Jul 3. doi: 10.1093/jn/nxy116.

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