It is the opinion of many functional medicine doctors, including myself, that chronic diseases are directly or indirectly related to chronic systemic inflammation. This article evaluates and affirm the inverse relationship between Omega 3 fatty acids found in fish oils intake and CRP (Inflammatory Marker)

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Background/Objectives:

N-3 polyunsaturated fatty acids (PUFAs) have been associated with reduced inflammation. We tested the hypothesis that high serum concentrations of the n-3 PUFAs are associated with lower serum C-reactive protein (CRP) concentrations in healthy middle-aged Finnish men. We also examined whether exposure to mercury, an environmental contaminant in fish, which is also a major source of long-chain n-3 PUFA, was associated with CRP.

Subjects/Methods:

Data from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study were analyzed cross-sectionally to determine the associations between serum n-3 PUFAs, hair mercury and serum CRP in 1395 healthy men, aged 42–60 years. Linear regression analyses were performed to analyze the associations.

Results:

In the multivariate models, the mean serum CRP in quartiles of serum total n-3 PUFA concentration was 1.23, 1.27, 1.18 and 1.08?mg/l, Pfor trend=0.01. Statistically significant inverse associations were also observed with the total serum long-chain n-3 PUFA concentration and with the individual long-chain n-3 PUFAs docosapentaenoic acid and docosahexaenoic acid, but not with eicosapentaenoic acid or with the intermediate-chain n-3 PUFA alpha-linolenic acid. Hair methylmercury content was not associated with serum CRP levels and it did not modify the associations between serum n-3 PUFAs and CRP either.

Conclusions:

Serum n-3 PUFAs and especially the long-chain n-3 PUFA concentration, a marker of fish or fish oil consumption, were inversely associated with serum CRP in men. Exposure to mercury was not associated with serum CRP.

Reference:

http://www.nature.com/ejcn/journal/v66/n6/abs/ejcn2011195a.html

 

About the author: Dr. Mordy Levy

 

Dr. Mordy Levy, ND, DC, HOM, is possibly the only Canadian doctor to have graduated from three first professional doctorates in separate and distinct health care professions: Chiropractic Medicine (DC)-1997, Allopathic Medicine (MD)-2006, Naturopathic Medicine (ND)-2011, graduated Summa Cum Laude, from the prestigious National University of Health Sciences (Chicago, IL) and was the valedictorian of his graduating class.

Dr Levy's first undergraduate degree (BSc) was in Biology and Psychology from York University, and his second undergraduate degree (BMSc) was in Human Biology and Biomedical sciences from National University of Health Sciences (Chicago, IL)

Dr. Levy is a registered member in good standing with three distinct health professions in Ontario, namely the College of Chiropractors of Ontario, the College of Naturopaths of Ontario, in addition to the College of Homeopaths of Ontario. Dr. Levy is a professional member of the Institute of Functional Medicine, the Canadian Society of Orthomolecular Medicine, American College of Nutrition, in addition to the Ontario Association of Naturopathic Doctors, the Ontario Chiropractic Association and the Ontario Homeopathic Association. Always an avid lifelong learner, Dr. Levy completed numerous postgraduate certifications in Functional Medicine, Clinical Nutrition, Medical Acupuncture, Homeopathic Medicine, in addition to Prolotherapy regenerative medicine. His clinical interests are in Neurological, Autoimmune and Gastrointestinal Dysfunctions.
On a personal noted: Dr. Levy enjoys spending time with his three boys, practicing TaeKwonDo and reviewing research articles.

Website: http://www.DrLevy.ca