How does Lecithin work? Lecithin (fat found in sunflower seeds, egg yolks or soybeans) is converted into acetylcholine, a substance that transmits nerve impulses. This study evaluates the safety and efficacy of Lecithin, specifically PS (Phosphotidylserine) on Mood, memory and cognition in elderly AD patients.

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Positive Effects of Soy Lecithin-Derived Phosphatidylserine plus Phosphatidic Acid on Memory, Cognition, Daily Functioning, and Mood in Elderly Patients with Alzheimer’s Disease and Dementia

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Introduction

We report previously unpublished, early pilot studies performed with a brain-health food supplement containing a proprietary blend of 100 mg phosphatidylserine (PS) and 80 mg phosphatidic acid (PA) produced from soy lecithin.

Methods

Serum analysis after single PS+PA ingestion was performed in healthy volunteers. A 3-month double-blind, placebo-controlled study assessed the influence of three PS+PA capsules/day, (300 mg PS + 240 mg PA/day) or placebo on memory and mood in functioning, non-depressive elderly people with memory problems, using the Wechsler Memory Scale and the List of Depressive Symptoms. Furthermore, a 2-month randomized, double-blind, placebo-controlled trial assessed the effect of three PS+PA capsules/day (300 mg PS + 240 mg PA/day) or placebo on daily functioning, mental health, emotional state, and self-reported general condition in patients with Alzheimer’s disease (AD).

Results

Serum PS peaked 90 min after ingestion, returning to baseline after 180 min. In the elderly, PS+PA [per protocol (PP) n = 31], unlike placebo (PP n = 26), significantly improved memory and prevented “winter blues” in a pre–post comparison. In the patients with AD, daily functioning (i.e., 7 activities of daily living) under PS+PA (PP n = 53) remained unchanged, but declined from 5.62 to 4.90 under placebo (PP n = 39; P = 0.035), with significant group difference (P = 0.021). The PS+PA group had 3.8% deterioration and 90.6% stability in daily functioning, compared to 17.9% and 79.5% under placebo, respectively (P = 0.066). Forty-nine percent of the PS+PA patients reported an improved general condition, compared to 26.3% under placebo (P = 0.084). Approximately, 43% of the PS+PA patients, but none under placebo, continued post-trial supplementation (while double-blinded). No negative side effects were observed.

Conclusion

PS is efficiently absorbed after oral consumption. A positive influence of PS+PA on memory, mood, and cognition was demonstrated among elderly test subjects. Short-term supplementation with PS+PA in patients with AD showed a stabilizing effect on daily functioning, emotional state and self-reported general condition. The data encourage long-term studies with PS+PA in AD patients and other elderly with memory or cognition problems.

Reference: 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271139/

 

 

About the author: Dr. Mordy Levy

 

Dr. Mordy Levy, ND, DC, HOM, is possibly the only Canadian doctor to have graduated from three first professional doctorates in separate and distinct health care professions: Chiropractic Medicine (DC)-1997, Allopathic Medicine (MD)-2006, Naturopathic Medicine (ND)-2011, graduated Summa Cum Laude, from the prestigious National University of Health Sciences (Chicago, IL) and was the valedictorian of his graduating class.

Dr Levy's first undergraduate degree (BSc) was in Biology and Psychology from York University, and his second undergraduate degree (BMSc) was in Human Biology and Biomedical sciences from National University of Health Sciences (Chicago, IL)

Dr. Levy is a registered member in good standing with three distinct health professions in Ontario, namely the College of Chiropractors of Ontario, the College of Naturopaths of Ontario, in addition to the College of Homeopaths of Ontario. Dr. Levy is a professional member of the Institute of Functional Medicine, the Canadian Society of Orthomolecular Medicine, American College of Nutrition, in addition to the Ontario Association of Naturopathic Doctors, the Ontario Chiropractic Association and the Ontario Homeopathic Association. Always an avid lifelong learner, Dr. Levy completed numerous postgraduate certifications in Functional Medicine, Clinical Nutrition, Medical Acupuncture, Homeopathic Medicine, in addition to Prolotherapy regenerative medicine. His clinical interests are in Neurological, Autoimmune and Gastrointestinal Dysfunctions.
On a personal noted: Dr. Levy enjoys spending time with his three boys, practicing TaeKwonDo and reviewing research articles.

Website: http://www.DrLevy.ca