High-dose Omega-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial.



Combined omega-3 fatty acid and vitamin D3 supplementation may improve multiple sclerosis (MS) by correcting metabolic abnormalities and attenuating oxidative stress and inflammation.


This study aimed to determine the effects of Omega-3 fatty acid and vitamin D3 co-supplementation on the disability score and metabolic status of patients with MS.


This was a randomized, placebo-controlled clinical trial with Expanded Disability Status Scale (EDSS) score and inflammation as primary outcomes and oxidative stress biomarkers and metabolic profile as secondary outcomes. Patients, aged 18-55 y, were matched for disease EDSS scores, gender, medications, BMI, and age (n = 53) and randomly received a combined 2 × 1000 mg/d  Omega-3 fatty acid and 50,000 IU/biweekly cholecalciferol supplement or placebo for 12 wk. The placebos were matched in colour, shape, size, packaging, smell, and taste with supplements. Fasting blood samples were collected at baseline and end of intervention to measure different outcomes. Multiple linear regression models were used to assess treatment effects on outcomes adjusting for confounding variables.


Patients taking Omega-3 fatty acid plus vitamin D3 supplements showed a significant improvement in EDSS (? -0.18; 95% CI: -0.33, -0.04; P = 0.01), compared with placebo. Serum high-sensitivity C-reactive protein (? -1.70 mg/L; 95% CI: -2.49, -0.90 mg/L; P < 0.001), plasma total antioxidant capacity (? +55.4 mmol/L; 95% CI: 9.2, 101.6 mmol/L; P = 0.02), total glutathione (? +51.14 µmol/L; 95% CI: 14.42, 87.87 µmol/L; P = 0.007), and malondialdehyde concentrations (? -0.86 µmol/L; 95% CI: -1.10, -0.63 µmol/L; P < 0.001) were significantly improved in the supplemented group compared with the placebo group. In addition, ?-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations.


Overall, taking Omega-3 fatty acid and vitamin D3 supplements for 12 wk by patients with MS had beneficial effects on EDSS and metabolic status.


Kouchaki E, Afarini M, Abolhassani J, Mirhosseini N, Bahmani F, Masoud SA,
Asemi Z. High-dose ?-3 Fatty Acid Plus Vitamin D3 Supplementation Affects
Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A
Randomized Controlled Clinical Trial. J Nutr. 2018 Jul 3. doi: 10.1093/jn/nxy116.


About the author: Dr. Mordy Levy


Dr. Mordy Levy, BSc, ND, DC, HOM, IMG, Graduated from three first professional degrees in separate and distinct health care professions. As a Doctor of Chiropractic (DC) in 1997 from the National College of Chiropractic, Chicago, Illinois, as a Doctor of Medicine (MD) in 2006 from the University of Health Sciences Antigua, School of Medicine and as a Doctor of Naturopathic Medicine (ND) in 2011, graduated Summa Cum Laude, from the National University of Health Sciences and was the valedictorian of his graduating class.

Dr Levy's first undergraduate degree (BSc) was in Biology and Psychology from York University and his second undergraduate degree (BSc) was in Human Biology and Biomedical sciences from National University of Health Sciences (Chicago, IL)

Dr. Levy is a registered member in good standing with three distinct health professions in Ontario, namely the College of Chiropractors of Ontario, the College of Naturopaths of Ontario, in addition to the College of Homeopaths of Ontario.

Dr. Levy is a professional member of the Institute of Functional Medicine, the Canadian Society of Orthomolecular Medicine, American College of Nutrition, in addition to the Ontario Association of Naturopathic Doctors, the Ontario Chiropractic Association and the Ontario Homeopathic Association.

Always an avid lifelong learner, Dr. Levy completed numerous postgraduate courses in Functional Medicine, Clinical Nutrition, Acupuncture and Homeopathy. His clinical interests are in digestive, autoimmune, fertility, chronic pain and hormonal health.

On a personal noted: Dr. Levy enjoys spending time with his three boys, practicing TaeKwonDo and reviewing research articles.

Website: http://www.DrLevy.ca